Batch HLA Typing Ingestion & Allele Resolution Studio
Stop losing hours of bench time to broken sequencing spreadsheets. Whether your external typing lab sends 50 donors or thousands of donor profiles at once, LABA verifies and locks clean records immediately, recovers Excel formatting damage automatically, and isolates only the exceptions for a rapid, guided review.
Ending the “Spreadsheet Surgery” Nightmare
Every immunogenetics lab, PBMC biorepository, and cell therapy facility knows the frustration when an external sequencing file arrives on a Friday afternoon—and a generic LIMS refuses to import it.
“Row 74 Failed—Import Aborted”
Clean Donors Go Live Immediately: LABA separates clean profiles from exceptions on arrival. Commit your 2,447 valid donors in one click so bench assays can proceed immediately, while only the 3 flagged rows wait for your review.
“Excel Turned 01:01 Into a Timestamp”
Automatic Spreadsheet Damage Recovery: You never have to rebuild a corrupted spreadsheet by hand. LABA recognises Excel formatting damage upon upload and restores the intended allele call automatically for your confirmation.
“Every Typing Lab Uses Different Formats”
11-Locus Clinical Standardisation: Automatically normalises multi-field calls to clean 4-digit clinical resolution across all 11 Class I and Class II loci, while natively accepting negative secondary loci and novel allele calls.
“Will This File Overwrite Verified Donors?”
Side-by-Side Freezer & Biobank Context: Before accepting any change, you see the donor's existing LABA typing alongside their exact count of active frozen vials in storage—with a 1-click guard to keep existing verified calls.
“Wasting Hours Explaining Errors by Email”
1-Click Vendor Query Sheet (.xlsx): Export a ready-to-send return workbook containing only the unresolved donor rows—with the exact error category, faulty locus, and diagnostic comment already filled in for the external lab.
“Assembling Audit Trails for QA Inspectors”
Instant Signed PDF Certificates: Generate a formal Landscape A4 Batch Ingestion Certificate or a Portrait A4 Single-Donor Resolution Dossier in under one second—complete with ALCOA+ attribution.
From Raw Vendor File to Verified Biobank in 3 Steps
Designed around how real immunogenetics scientists and biobank managers work—turning a tedious afternoon of data cleanup into a calm, 2-minute guided workflow.
Upload Hundreds or Thousands of Donors—Commit Clean Profiles Immediately
Drop your external sequencing workbook into the studio. Within seconds, LABA evaluates every allele across all 11 Class I (HLA-A, B, C) and Class II (DRB1, DRB3/4/5, DQA1, DQB1, DPA1, DPB1) loci.
- ✔ Clean Rows Lock Automatically: Valid donor profiles are marked Ready · Locked so they cannot be accidentally altered during review.
- ✔ Immediate Cohort Release: Click Commit Valid Donors to release all 2,447 clean donors to your biobank right away while isolating the 2 exceptions.
- ✔ Instant Allele & Cohort Filtering: Filter across thousands of donors by Donor ID, Reference Code, Status, or specific allele call (e.g.
01:01) in real time.
See Existing Biobank Typing & Active Frozen Vials Side by Side
When a row needs attention—such as an unrecognised donor barcode, an incomplete allele pair, or an updated call for an existing donor—LABA opens the Guided Resolution View.
- ✔ Live Cryostorage Visibility: Immediately see whether the donor already has active vials stored in your freezers (e.g. 14 active vials in cryostorage) before approving any update.
- ✔ Side-by-Side Locus Diffing: Compare Existing in LABA vs. Inbound File locus by locus, with 1-click protection to preserve verified historical typing.
- ✔ Non-Destructive Rollback: Every original vendor row is preserved in an immutable audit shadow record so you can revert any edit back to the raw vendor state at any time.
1-Click Vendor Query Workbook (.xlsx) & Signed Audit Certificates (PDF)
Close the loop with external sequencing laboratories and internal Quality Assurance without typing a single summary email or formatting a report.
- ✔ Pre-Filled Vendor Query Sheet (.xlsx): Exports only the unresolved donor rows with pre-populated diagnostic notes—ready to send back to the external typing facility for re-sequencing.
- ✔ Sub-Second Batch & Donor PDFs: Generate a signed Batch HLA Ingestion Certificate (PDF) or a Single-Donor Resolution Dossier (PDF) in under one second.
- ✔ Perpetual Audit Readiness: Every action is permanently linked to the authenticated scientist, UTC timestamp, and specimen lineage in full alignment with ALCOA+ governance.
Experience 1-Click Batch HLA Relief
Click the filter pills or 1-click resolution buttons below to see how scientists clear spreadsheet exceptions in seconds without delaying clean donors.
| Status | Donor ID | Active Vials | HLA-A | HLA-B | DRB1 | DQB1 | Guided Action |
|---|---|---|---|---|---|---|---|
| 🔒 Ready · Locked | DNR-10401 | 18 vials (-196°C) | 01:01 / 03:01 ✓ | 07:02 / 08:01 ✓ | 03:01 / 15:01 ✓ | 02:01 / 06:02 ✓ | Verified on intake |
| ⚠ Excel Damaged | DNR-10402 | 12 vials (-196°C) | [Excel Time-Decimal] / 24:02 | 15:01 / 35:01 ✓ | 04:01 / 11:01 ✓ | 03:01 / 03:02 ✓ | |
| ⚠ Multi-Field NGS | DNR-10403 | 14 vials (-196°C) | 01:01 / 11:01 ✓ | 07:02 / 15:17 ✓ | 04:01 / 13:02 ✓ | 03:02:01:01 / 06:04G | |
| ⚠ Existing Donor Diff | DNR-10404 | 22 vials (-196°C) | 02:01 / 02:11 ✓ | Inbound 35:01 vs Lab 35:03 | 09:01 / 14:02 ✓ | 03:01 / 03:03 ✓ | |
| ✔ Corrected | DNR-10405 | 9 vials (-80°C) | 03:01 / 11:01 ✓ | 18:01 / 35:01 ✓ | 04:04 / 15:01 ✓ | 03:02 / 06:02 ✓ | Audit shadow row preserved |
| Laboratory Intake Challenge | Standard Spreadsheet / Legacy LIMS | The LABA Batch HLA Studio |
|---|---|---|
| Batch Failure Handling | All-or-nothing crash; 1 typo blocks 2,000 donors | Clean donors lock & commit immediately; exceptions isolated |
| Excel Time-Decimal Damage | Silent corruption of 01:01 alleles; manual re-typing | Automatic detection & restoration of damaged allele calls |
| NGS Multi-Field Notation | Mixed 4/6/8-digit strings break cohort matching | Automatic normalisation to 4-digit clinical resolution |
| Secondary & Novel Loci | Rejects DRB3/4/5 negative calls or novel alleles | Native support across all 11 Class I & II loci + novel calls |
| Freezer Vial Protection | Blindly overwrites historical donor typing records | Side-by-side comparison with active frozen vial inventory |
| Vendor & QA Deliverables | Hours of manual emails and audit report preparation | 1-click Unresolved Vendor (.xlsx) & Signed Audit PDF (<1s) |
Connect donor HLA profiles directly to Specimen & Aliquot Lineage Tracking, map cryotanks in Virtual Storage Matrices, or evacuate freezers with Storage Relocation.
Explore Legacy Data Migration →Frequently Asked Questions: Batch HLA Typing Intake
Answers to common questions from immunogenetics directors, PBMC repository managers, and clinical research teams.
How many donor HLA profiles can LABA import in a single batch?
LABA handles any batch size—from a single donor plate to thousands of donor profiles in one upload. Valid donor records are verified and locked immediately so your clean cohort goes live in seconds without waiting on a handful of flagged rows.
How does LABA fix Excel changing HLA alleles like 01:01 into decimals or timestamps?
When external spreadsheets are opened in Microsoft Excel, alleles such as 01:01 or 02:01 are frequently corrupted into time-fractions or decimal values. LABA automatically detects spreadsheet formatting damage upon intake and restores the intended HLA allele call for scientist verification without manual cell-by-cell re-typing.
Which HLA Class I and Class II loci are supported out of the box?
The studio natively manages all 11 paired clinical loci across Class I (HLA-A, HLA-B, HLA-C) and Class II (DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1, DPB1), including homozygous calls, negative secondary loci (NEG / -), and novel allele designations.
What happens if an external sequencing file contains 6-digit or 8-digit NGS allele strings?
External sequencing laboratories often deliver mixed 4-digit, 6-digit, and 8-digit Next-Generation Sequencing (NGS) notations. LABA automatically normalises multi-field calls to clean 4-digit clinical resolution so every donor search across your biorepository remains uniform and reliable.
How does LABA prevent a batch upload from overwriting existing verified donor typing?
Before any modified allele is committed, LABA displays a side-by-side comparison showing the donor's existing biobank typing alongside their active frozen vial inventory count. Scientists can preserve existing verified typing in one click.
How do we handle unresolved donor rows that require re-testing by the external typing vendor?
While your clean donors are committed immediately to the biobank, clicking the Unresolved (.xlsx) button exports a clean return workbook containing only the problem rows—with the exact error category, faulty locus, and diagnostic note already filled in—ready to email back to the external sequencing lab.
Does the module generate audit documentation for ISO 20387:2018 and FDA 21 CFR Part 11 inspections?
Yes. LABA is engineered with native technical controls required to support institutional compliance with FDA 21 CFR Part 11, EU Annex 11, GAMP 5, and ISO 20387:2018. In under one second, scientists can generate a signed Batch HLA Ingestion Certificate (PDF) or a Single-Donor HLA Resolution Dossier (PDF) with full ALCOA+ attribution.
Can we test the Batch HLA Typing Studio with our own historical donor spreadsheets before purchasing?
Yes. You can book a 15-minute live walkthrough where we run an anonymised sample of your donor spreadsheets live, or commission the Stage 1 Universal 45-Day Proof-of-Concept Pilot (£8,500 excl. VAT, 100% credited toward full deployment) to validate the entire platform with your team.
Ready to Eliminate Spreadsheet Surgery?
Send us an anonymised sample of your donor HLA spreadsheets for a live 15-minute walkthrough, or evaluate LABA across your entire biorepository with our 100%-credited 45-Day Pilot.
